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in Laguna鈥攔oughly 65 kilometers south of Manila鈥攊s the country鈥檚 recognized leader in agriculture, forestry, and environmental management. Because of its location at the foot of Mt. Makiling and its fields of expertise, it is host to two international research institutions: the International Rice Research Institute and the Southeast Asian Ministers of Education Organization Regional Center for Graduate Study and Research in Agriculture. As a pioneer in forest conservation, UP Los Ba帽os has stewardship over the 4,244-hectare Mt. Makiling Forest Reserve.

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is the leading academic institution in the health sciences. It is home to the National Institutes of Health and the UP Philippine General Hospital, the country鈥檚 largest government tertiary hospital. The UP Manila College of Nursing is the World Health Organization鈥檚 Regional Collaborating Center in Nursing Development, while the College of Public Health is the Southeast Asian Ministers of Education Organization Regional Network in Tropical Medicine and Public Health Regional Center for Public Health. It has also established extension campuses of its School of Health Sciences in Luzon (Baler, Aurora), Visayas (Palo, Leyte), and Mindanao (Koronadal, South Cotabato).

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with its three campuses in Iloilo City, Iloilo and Miag-ao, Iloilo, is the acknowledged authority in marine science education and research, fisheries, and aquaculture in the country. Its research endeavors are supported by the following facilities: Brackishwater Aquaculture Center, Freshwater Aquaculture Station, Batan Mariculture Station, and Marine Biological Station. It is also the base agency of the Western Visayas Agriculture and Resources Research and Development Consortium. Apart from its focus on the sciences, this constituent university also prioritizes the preservation and enrichment of Visayan cultural heritage.

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is the pioneer institution in distance education and open learning in the Philippines. While its base of operations is in Los Ba帽os, Laguna, it is basically a virtual university鈥攑roviding quality education to students in the country and abroad who are not able to attend conventional colleges and universities due to personal or professional constraints. At the UP Open University, students learn at their own pace and convenience. It has ten learning centers with 19 testing centers all over the country. For its students abroad, it has a virtual learning center to address their academic concerns. Examinations for these students, meanwhile, are either administered online or in the Philippine Consulates.

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attained its status as constituent university in 2002. It is a leading institution in the areas of science and mathematics, social sciences, and the humanities in Northern Philippines. Through its research arm, the Cordillera Studies Center, UP Baguio contributes to higher education by focusing on the preservation of the cultural traditions of the Cordilleras, Northern Luzon, and Cagayan Valley.

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, formerly one of the UP Visayas campuses, became an autonomous college under the UP Office of the President in September 2010. Autonomy was granted to better serve the needs of its region鈥攁 region that is aggressively asserting itself as an area for direct and foreign investments. This is why its focus is on the strengthening of its information technology and business programs. In 2016, UP Cebu was declared a constituent university of the UP System.

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, previously under UP Visayas, was elevated to an autonomous college under the Office of the UP President in 2023. It has four academic divisions offering 10 undergraduate programs鈥攊n Literature, Media Arts, Psychology, Biology, Political Science, Economics, Applied Mathematics, Computer Science, Accountancy, and Management鈥攁nd two graduate programs in Environmental Science and Management. It also hosts the Leyte-Samar Heritage Center and the Regional Environmental Information Systems (REIS) Laboratory.

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